Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 8/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966603 | 0.96 | PLK1 (0.43) | ACACBFFAR1PTGESUTS2RPLK1 | |
| SCHEMBL4978882 | 0.89 | PLK1 (0.47) | UTS2RPLK1CYP1A2CYP2C9 | |
| SCHEMBL1852713 | 0.88 | ACACB (0.51) | ACACB | |
| SCHEMBL1851806 | 0.87 | FFAR1 (0.50) | ACACBFFAR1CYP1A2CYP2C9 | |
| SCHEMBL5039404 | 0.80 | ACACB (0.39) | ACACBFFAR1PTGESUTS2RCYP1A2 | |
| SCHEMBL1852984 | 0.79 | MLYCD (0.51) | PLK1CYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL6718959 | 0.78 | SOAT1 (0.52) | UTS2R | |
| SCHEMBL1855570 | 0.77 | MTTP (0.44) | ACACBUTS2RCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6719336 | 0.76 | PTGES (0.42) | FFAR1PTGESCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1855001 | 0.76 | PPARG (0.39) | FFAR1UTS2RCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904048-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007009959-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2007-01-25 | — | — | WO | claimed |
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |