Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 14/20 | 0.53 |
| ▸ | DRD3 | P35462 | 12/20 | 0.53 |
| ▸ | DRD4 | P21917 | 7/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808300 | 0.85 | CCR2 (0.48) | CCR2DRD2DRD3DRD4ADRA1A | |
| SCHEMBL6806505 | 0.82 | CCR3 (0.55) | CCR2DRD2DRD3DRD4HTR1A | |
| SCHEMBL6710630 | 0.81 | CCR2 (0.53) | CCR2DRD2DRD3DRD4ADRA1A | |
| Hydrochloric Acid SCHEMBL6811480 | 0.81 | DRD2 (0.51) | CCR2DRD2DRD3DRD4ADRA1A | |
| SCHEMBL3109401 | 0.81 | DRD2 (0.51) | CCR2DRD2DRD3DRD4ADRA1A | |
| SCHEMBL6724395 | 0.76 | DRD2 (0.49) | DRD2DRD3DRD4 | |
| SCHEMBL6720905 | 0.75 | SLC6A4 (0.54) | DRD2DRD3DRD4 | |
| SCHEMBL5937227 | 0.75 | DRD2 (0.44) | CCR2DRD2DRD3DRD4HTR1A | |
| SCHEMBL1542774 | 0.75 | DRD2 (0.43) | CCR2DRD2DRD3DRD4ADRA1A | |
| SCHEMBL5937250 | 0.74 | DRD2 (0.47) | CCR2DRD2DRD3DRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673555-B1 | USE OF SREBP CLEAVAGE-ACTIVATING PROTEIN (SCAP) TO SCREEN FOR AGENTS HAVING SCAP BINDING CHARACTERISTICS; USE IN COMBATING DISEASES ASSOCIATED WITH ELEVATED BLOOD LIPID LEVELS; SREBP: STEROL REGULATORY ELEMENT BINDING PROTEIN | SMITHKLINE BEECHAM CORPORATION | 2004-01-06 | — | — | US | disclosed |
| US-20030224347-A1 | Pharmaceutical compositions | GRAND-PERRET THIERRY ANDRE REG (FR) | 2003-12-04 | — | — | US | disclosed |