⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7613149 | 0.81 | — | — | |
| SCHEMBL588585 | 0.79 | CYP1A2 (0.36) | — | |
| SCHEMBL9628543 | 0.77 | MAPT (0.39) | — | |
| SCHEMBL15091498 | 0.75 | — | — | |
| SCHEMBL21846959 | 0.73 | — | — | |
| SCHEMBL18425753 | 0.71 | — | — | |
| SCHEMBL20176035 | 0.71 | — | — | |
| SCHEMBL4320494 | 0.67 | — | — | |
| SCHEMBL1784891 | 0.67 | — | — | |
| SCHEMBL1533811 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107973780-B | Substituted olefin compound and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2020-10-09 | — | — | CN | disclosed |
| US-6673930-B2 | PREPARING A SELECTIVE GLUCOCORTICOID RECEPTOR AGENTS BY CYCLIZATION, DEHALOGENATION, AMINATION, ETHERIFICATION, HYDROXYLATION | ABBVIE INC. | 2004-01-06 | — | — | US | disclosed |
| US-20030069427-A1 | Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof | ABBVIE INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2003027117-A1 | A PROCESS FOR THE PREPARATION OF 5-(SUBSTITUTED)-10-METHOXY-2,2,4-TRIMETHYL-2,5-DIHYDRO-1H-CHROMENO[3,4-F]QUINOLINES AND DERIVATIVES THEREOF | ABBOTT LABORATORIES (US) | 2003-04-03 | — | — | WO | disclosed |
| US-6518430-B1 | The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5- dihydro-1H-chromeno(3,4-f)quinolines. | ABBOTT LABORATORIES | 2003-02-11 | — | — | US | disclosed |
| EP-1105416-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF EXOCHELINS | Keystone Biomedical, Inc. (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000009547-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF EXOCHELINS | KEYSTONE BIOMEDICAL, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| EP-0339516-B1 | CATALYST AND PROCESS FOR THE PREPARATION OF POLYMERS OF TRI-SUBSTITUTED SILYLALKYNES | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-4902763-A | USING GROUP V OR VI METAL HALIDE CATALYST AND TRIALKYLGERMYALKYNE COMPOUND PROMOTER | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0343556-A2 | Process for the polymerization of tri-substituted silylalkynes | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0339516-A2 | Catalyst and process for the preparation of polymers of tri-substituted silylalkynes | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4835229-A | METAL HALIDE, TERTIARY AMINE | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-05-30 | — | — | US | disclosed |