Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628543 | 0.97 | MAPT (0.39) | CYP1A2CYP2D6MAPTCYP2C9CYP2C19 | |
| SCHEMBL7613149 | 0.92 | — | — | |
| SCHEMBL6720442 | 0.79 | — | — | |
| SCHEMBL4219194 | 0.77 | CYP1A2 (0.37) | CYP1A2CYP2D6MAPTCYP2C9CYP2C19 | |
| SCHEMBL20390547 | 0.74 | MGAM (0.31) | — | |
| SCHEMBL1062616 | 0.74 | — | — | |
| SCHEMBL12677766 | 0.72 | TSHR (0.46) | MAPTALDH1A1CYP3A4 | |
| SCHEMBL4234450 | 0.71 | MGAM (0.33) | — | |
| SCHEMBL12677847 | 0.71 | MGAM (0.33) | — | |
| SCHEMBL2520528 | 0.71 | MAPT (0.55) | CYP1A2CYP2D6MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436824-B1 | Low dielectric constant materials for copper damascene | CHARTERED SEMICONDUCTOR MANUFACTURING LTD. (SG) | 2002-08-20 | — | — | US | claimed |
| EP-1753746-B8 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM SPA (IT) | 2012-02-15 | — | — | EP | disclosed |
| EP-1753746-B1 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM SPA (IT) | 2011-07-27 | — | — | EP | disclosed |
| US-7906501-B2 | Pyrrole derivatives with angiotensin II antagonist activity | ROTTAPHARM S.P.A. (IT) | 2011-03-15 | — | — | US | disclosed |
| US-20070244170-A1 | Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity | ROTTAPHARM BIOTECH S.R.L. (IT) | 2007-10-18 | — | — | US | disclosed |
| EP-1753746-A2 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM S.P.A. (IT) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005105789-A2 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM S.P.A. (IT) | 2005-11-10 | — | — | WO | disclosed |
| US-6436824-B1 | Low dielectric constant materials for copper damascene | CHARTERED SEMICONDUCTOR MANUFACTURING LTD. (SG) | 2002-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244170-A1 | Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity | AGTR2, AGTR1, REN | CYP1A2 2807/4885CYP2D6 2450/4885MAPT 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.