SCHEMBL6720686

SCHEMBL6720686

CSc1cc(C(F)(C(C)(F)F)C(F)(F)F)cc(Cl)c1NC(=O)c1ccc(C#N)c(N)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.36
KMT2A Q03164 6/20 0.36
MEN1 O00255 5/20 0.36
CYP2C9 P11712 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
S1PR3 Q99500 4/20 0.35
S1PR1 P21453 2/20 0.35
ALDH1A1 P00352 2/20 0.34
POLB P06746 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
THRB P10828 1/20 0.34
RECQL P46063 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3705856 0.93 KMT2A (0.36) ARKMT2AMEN1CYP2C9CYP1A2
SCHEMBL6720689 0.86 MAPT (0.43) ARKMT2AMEN1CYP2C9CYP1A2
SCHEMBL299598 0.85 KCNQ3 (0.39) ARKMT2AMEN1S1PR3S1PR1
SCHEMBL3705809 0.83 KCNQ3 (0.38) ARKMT2AMEN1S1PR3S1PR1
SCHEMBL299995 0.81 KCNQ3 (0.36) ARKMT2AMEN1S1PR3S1PR1
SCHEMBL3702064 0.79 MAPT (0.43) KMT2AMEN1S1PR3S1PR1ALDH1A1
SCHEMBL3695537 0.79 KCNQ3 (0.35) ARKMT2AMEN1S1PR3S1PR1
SCHEMBL299030 0.78 KMT2A (0.48) KMT2AMEN1CYP2C9CYP1A2CYP3A4
SCHEMBL3011716 0.78 LCK (0.41) ARS1PR3KCNQ3KCNQ2KCNE1
SCHEMBL18724258 0.77 JAK2 (0.40) KMT2AMEN1KDM4EKCNJ11TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8431514-B2 4-cyano-3-benzoylamino-N-phenyl-benzamides for use in pest control SYNGENTA CROP PROTECTION LLC (US) 2013-04-30 US disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL NISCH, AADAC, ACHE AR 3556/4885KMT2A 901/4885MEN1 4616/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.