Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 14/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | XBP1 | P17861 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272964 | 0.86 | THRA (0.52) | MRGPRX4NPC1TP53XBP1RAB9A | |
| SCHEMBL4265967 | 0.86 | F2 (0.49) | MRGPRX4TP53RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1457712 | 0.85 | MEN1 (0.63) | MRGPRX4NPC1TP53XBP1RAB9A | |
| SCHEMBL22480969 | 0.80 | NPC1 (0.74) | MRGPRX4NPC1TP53XBP1RAB9A | |
| SCHEMBL6725147 | 0.78 | NR4A2 (0.62) | MRGPRX4NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL6721220 | 0.78 | RXRA (0.64) | MRGPRX4NPC1TP53XBP1RAB9A | |
| SCHEMBL4931492 | 0.77 | THRA (0.46) | MRGPRX4SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL16351377 | 0.76 | MRGPRX4 (0.68) | MRGPRX4NPC1TP53XBP1RAB9A | |
| SCHEMBL4901522 | 0.75 | GLRA1 (0.65) | MRGPRX4NPC1TP53XBP1RAB9A | |
| SCHEMBL10323084 | 0.74 | KDM4E (0.64) | MRGPRX4NPC1TP53XBP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638977-B1 | Biaryl and benzyl ethers and thioethers | CORVAS INTERNATIONAL, INC. | 2003-10-28 | — | — | US | claimed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | claimed |
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |