Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | UBE2I | P63279 | 4/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721977 | 0.91 | POLB (0.51) | POLBUBE2ISAE1UBA2TP53 | |
| SCHEMBL6722119 | 0.91 | POLB (0.51) | POLBUBE2ISAE1UBA2TP53 | |
| SCHEMBL6722180 | 0.91 | POLB (0.51) | POLBUBE2ISAE1UBA2TP53 | |
| SCHEMBL6721764 | 0.73 | PTGES (0.58) | POLBPTGESALDH1A1NPSR1MAPT | |
| SCHEMBL6721747 | 0.72 | PTGES (0.56) | POLBPTGESALDH1A1NPSR1MAPT | |
| SCHEMBL6721714 | 0.72 | PTGES (0.56) | POLBPTGESALDH1A1ALOX15TSHR | |
| SCHEMBL6721838 | 0.70 | PTGES (0.52) | POLBPTGESALDH1A1NPSR1MAPT | |
| SCHEMBL6721890 | 0.70 | PTGES (0.52) | POLBPTGESALDH1A1MAPTMEN1 | |
| SCHEMBL6721831 | 0.69 | PTGES (0.59) | POLBPTGESALDH1A1NPSR1MAPT | |
| SCHEMBL6721785 | 0.69 | PTGES (0.51) | POLBPTGESALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | TYMP, IMPDH1, SAMHD1 | POLB 26/4885UBE2I 2756/4885SAE1 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.