SCHEMBL6722700

SCHEMBL6722700

Nc1cc(-c2ncnc(C(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 6/20 0.33
PRKDC P78527 5/20 0.33
RET P07949 1/20 0.31
KIF5B P33176 1/20 0.31
KDR P35968 1/20 0.31
CCDC6 Q16204 1/20 0.31
GAA P10253 1/20 0.31
KIT P10721 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6718668 0.88 GAA (0.32) GAA
SCHEMBL6719105 0.83 KCNH2 (0.33) KCNH2PRKDCKDR
SCHEMBL6718949 0.83 KCNH2 (0.31) KCNH2PRKDC
SCHEMBL6719294 0.83 KHK (0.38) PRKDCKDRKIT
SCHEMBL6719107 0.81 KCNH2 (0.30) KCNH2
SCHEMBL6718271 0.80 CA1 (0.35) PRKDCKIT
SCHEMBL6715765 0.80 KCNH2 (0.39) KCNH2PRKDCKDRKIT
SCHEMBL6727013 0.80 PRKDC (0.32) KCNH2PRKDC
SCHEMBL6718295 0.80 PRKDC (0.34) KCNH2PRKDC
SCHEMBL6727271 0.79 TRPV4 (0.38) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2004-05-13 US disclosed
CN-1473155-A Pyrimidine derivatives and herbicides containing the same ס������ũҩ��ʽ���� 2004-02-04 CN disclosed
EP-1333029-A1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Sumitomo Chemical Takeda Agro Company, Limited (JP) 2003-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same DDX41, CBR3, DPYD KCNH2 371/4885PRKDC 2318/4885RET 1433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.