SCHEMBL6718271

SCHEMBL6718271

NS(=O)(=O)c1cc(-c2ncnc(C(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 17/20 0.35
CA2 P00918 17/20 0.35
CA12 O43570 12/20 0.35
CA9 Q16790 12/20 0.35
CA4 P22748 4/20 0.35
CA6 P23280 4/20 0.35
CA5A P35218 4/20 0.35
CA7 P43166 4/20 0.35
CA14 Q9ULX7 4/20 0.35
CA5B Q9Y2D0 4/20 0.35
CA3 P07451 3/20 0.35
KIT P10721 1/20 0.34
CA13 Q8N1Q1 3/20 0.32
CISD1 Q9NZ45 1/20 0.32
LMNA P02545 1/20 0.31
CYP2C9 P11712 1/20 0.31
PRKDC P78527 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6727271 0.89 TRPV4 (0.38) KIT
SCHEMBL6719707 0.82 GSTO1 (0.34) KIT
SCHEMBL6719105 0.80 KCNH2 (0.33) PRKDC
SCHEMBL6722700 0.80 KCNH2 (0.33) KITPRKDC
SCHEMBL6718949 0.78 KCNH2 (0.31) PRKDC
SCHEMBL6715936 0.76 KMO (0.35) PRKDC
SCHEMBL6718059 0.75 KIT (0.36) KIT
SCHEMBL6719107 0.75 KCNH2 (0.30)
SCHEMBL6718543 0.75 DHFR (0.33) KITCYP2C9
SCHEMBL6715765 0.74 KCNH2 (0.39) KITPRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2004-05-13 US disclosed
CN-1473155-A Pyrimidine derivatives and herbicides containing the same ס������ũҩ��ʽ���� 2004-02-04 CN disclosed
EP-1333029-A1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Sumitomo Chemical Takeda Agro Company, Limited (JP) 2003-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same DDX41, CBR3, DPYD CA1 2678/4885CA2 962/4885CA12 4310/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.