Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 8/20 | 0.38 |
| ▸ | MMP9 | P14780 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 6/20 | 0.37 |
| ▸ | MMP1 | P03956 | 5/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.37 |
| ▸ | MMP14 | P50281 | 3/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719070 | 0.86 | DUT (0.53) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6719278 | 0.83 | DUT (0.56) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6724138 | 0.82 | DUT (0.55) | DUTMMP2MMP9KDM4ELMNA | |
| SCHEMBL6719663 | 0.81 | DUT (0.56) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6723951 | 0.80 | DUT (0.54) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6719761 | 0.80 | DUT (0.52) | DUTKDM4E | |
| SCHEMBL6730992 | 0.80 | DUT (0.52) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6722436 | 0.79 | DUT (0.53) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6723955 | 0.79 | DUT (0.55) | DUTMMP2MMP9ADAMTS5LMNA | |
| SCHEMBL6719609 | 0.78 | DUT (0.56) | DUTMMP2MMP9ADAMTS5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |