Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | FABP1 | P07148 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135844 | 0.87 | NPC1 (0.48) | KDM4EPOLBCES2CES1PGR | |
| SCHEMBL6135835 | 0.86 | TPMT (0.58) | TPMTKDM4EPOLBMRGPRX4CES2 | |
| SCHEMBL6723577 | 0.81 | CA1 (0.54) | TPMTKDM4ERAB9ALMNACA1 | |
| SCHEMBL4265055 | 0.79 | MRGPRX4 (0.64) | TPMTMRGPRX4RAB9AMEN1KMT2A | |
| SCHEMBL2867923 | 0.79 | AKR1C3 (0.73) | KDM4EPOLBMRGPRX4CES2CES1 | |
| SCHEMBL14024230 | 0.78 | TPMT (0.81) | TPMTKDM4ERAB9ALMNARXRA | |
| SCHEMBL1877592 | 0.78 | CA1 (0.63) | KDM4EPOLBPGRAKR1C3MTNR1A | |
| SCHEMBL6725156 | 0.77 | MRGPRX4 (0.51) | TPMTKDM4EPOLBMRGPRX4LMNA | |
| SCHEMBL6720943 | 0.76 | TPMT (0.50) | TPMTPOLBPGRLMNAAKR1C3 | |
| SCHEMBL9522943 | 0.76 | THRB (0.64) | TPMTKDM4EPOLBPGRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |