Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.44 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27939651 | 0.91 | CYP3A4 (0.46) | CYP3A4MAPK1LMNACYP19A1ABCB1 | |
| SCHEMBL5085611 | 0.91 | CYP3A4 (0.49) | CYP3A4MAPK1LMNACYP19A1ABCB1 | |
| SCHEMBL2879031 | 0.91 | ABCG2 (0.53) | CYP3A4MAPK1CYP19A1ABCB1MAOB | |
| SCHEMBL1164995 | 0.90 | ALDH1A1 (0.50) | CYP3A4MAPK1LMNAABCB1KDM4E | |
| SCHEMBL1164884 | 0.90 | ALDH1A1 (0.50) | CYP3A4MAPK1LMNAABCB1KDM4E | |
| SCHEMBL27974387 | 0.86 | CYP19A1 (0.47) | CYP3A4MAPK1LMNACYP19A1MAOB | |
| SCHEMBL3368235 | 0.81 | CYP19A1 (0.53) | CYP3A4MAPK1CYP19A1ALDH1A1HPGD | |
| SCHEMBL773768 | 0.81 | CYP19A1 (0.47) | CYP3A4MAPK1CYP19A1ALDH1A1HPGD | |
| SCHEMBL14829729 | 0.80 | CYP19A1 (0.52) | CYP3A4MAPK1CYP19A1ALDH1A1HPGD | |
| SCHEMBL7200862 | 0.80 | CYP1A1 (0.54) | CYP3A4MAPK1LMNACYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114224880-B | Application of 5,7,4' -trimethoxyflavone in preparing medicine for preventing and treating tumor | 中美（河南）荷美尔肿瘤研究院 | 2023-04-11 | — | — | CN | disclosed |
| US-6677350-B1 | ADMINISTERING CHALCONE-LIKE VINYLCARBONYL COMPOUNDS TO PREVENT OR TREAT MYCOBACTERIUM INFECTIONS/TUBERCULOSIS | ADVANCED LIFE SCIENCES, INC. | 2004-01-13 | — | — | US | disclosed |