Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31344375 | 0.76 | LMNA (0.48) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL671977 | 0.75 | POLB (0.44) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL29780042 | 0.67 | BCHE (0.59) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL150044 | 0.67 | BCHE (0.59) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL1429852 | 0.66 | POLB (0.43) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL28441996 | 0.66 | POLB (0.43) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL28438215 | 0.66 | POLB (0.43) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL16377053 | 0.65 | MEN1 (0.39) | LMNAALDH1A1CASP1MEN1KMT2A | |
| SCHEMBL11606236 | 0.65 | LMNA (0.43) | LMNAALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL31257224 | 0.65 | POLB (0.46) | LMNAALDH1A1HTTPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |