Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31344375 | 0.81 | LMNA (0.48) | POLBCYP1A2CYP2C19BCHEACHE | |
| SCHEMBL8998884 | 0.77 | ALDH1A1 (0.60) | POLBCYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL28441996 | 0.77 | POLB (0.43) | POLBCYP1A2CYP2C19BCHEACHE | |
| SCHEMBL672483 | 0.75 | LMNA (0.40) | POLBCYP1A2CYP2C19BCHEACHE | |
| SCHEMBL150044 | 0.71 | BCHE (0.59) | POLBCYP1A2CYP2C19BCHEACHE | |
| SCHEMBL29780042 | 0.71 | BCHE (0.59) | POLBCYP1A2CYP2C19BCHEACHE | |
| SCHEMBL22443301 | 0.71 | L3MBTL1 (0.52) | POLBCYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL28438215 | 0.70 | POLB (0.43) | POLBCYP1A2CYP2C19BCHEACHE | |
| SCHEMBL18977037 | 0.69 | LMNA (0.40) | POLBCYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL11606236 | 0.69 | LMNA (0.43) | POLBCYP1A2CYP2C19ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |