Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.55 |
| ▸ | RHEB | Q15382 | 2/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | FABP3 | P05413 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29205045 | 0.91 | MRGPRX4 (0.56) | MRGPRX4PTGER1FABP3FABP4FABP5 | |
| SCHEMBL6731841 | 0.89 | ACLY (0.56) | MRGPRX4PTGER1 | |
| SCHEMBL11349380 | 0.81 | MRGPRX4 (0.68) | MRGPRX4NR4A2SMN1; SMN2 | |
| SCHEMBL6725147 | 0.81 | NR4A2 (0.62) | MRGPRX4RHEBNR4A2MAPTSMN1; SMN2 | |
| SCHEMBL11574148 | 0.78 | KDM4E (0.68) | ALDH1A1TP53TSHRCASP1SMN1; SMN2 | |
| SCHEMBL12998984 | 0.76 | NR4A2 (0.63) | MRGPRX4NR4A2ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5059574 | 0.75 | CYP3A4 (0.54) | MAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8408730 | 0.75 | MAPT (0.51) | MRGPRX4RHEBNR4A2CCR5MAPT | |
| SCHEMBL4604502 | 0.75 | KDM4E (0.49) | MRGPRX4MAPTALDH1A1TP53TSHR | |
| SCHEMBL5839537 | 0.75 | FABP3 (0.67) | MRGPRX4RHEBNR4A2PTGER1FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | claimed |
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |