Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 7/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.48 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.48 |
| ▸ | TLK1 | Q9UKI8 | 2/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673441 | 0.93 | ALK (0.52) | KDRFLT1ALKPDGFRBFGFR1 | |
| SCHEMBL6722350 | 0.90 | KDR (0.51) | KDRFLT1ALKPDGFRBFGFR1 | |
| SCHEMBL2117957 | 0.82 | MEN1 (0.46) | KDRALKPDGFRBFGFR1KIT | |
| SCHEMBL2114496 | 0.81 | LRRK2 (0.42) | KDRALKPDGFRBFGFR1FLT3 | |
| SCHEMBL5642412 | 0.80 | MEN1 (0.42) | KDRFLT1ALKPDGFRBFGFR1 | |
| SCHEMBL6734453 | 0.80 | LRRK2 (0.41) | KDRFLT1ALKPDGFRBFGFR1 | |
| SCHEMBL6725660 | 0.79 | ALK (0.52) | KDRFLT1ALKPDGFRBFGFR1 | |
| SCHEMBL722802 | 0.79 | ALK (0.52) | KDRFLT1ALKPDGFRBFGFR1 | |
| SCHEMBL2114228 | 0.78 | SRC (0.45) | KDRALKPDGFRBFGFR1FLT3 | |
| SCHEMBL2113633 | 0.78 | MEN1 (0.41) | KDRFLT1ALKPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040152759-A1 | Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders | SUGEN, INC. | 2004-08-05 | — | — | US | claimed |
| US-20040152759-A1 | Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders | SUGEN, INC. | 2004-08-05 | — | — | US | disclosed |
| US-20030130280-A1 | Treatment of acute myeloid leukemia with indolinone compounds | SUGEN, INC. | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152759-A1 | Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders | MKI67, CCNA1, CCNI | KDR 3687/4885FLT1 2177/4885ALK 4375/4885 |
| US-20030130280-A1 | Treatment of acute myeloid leukemia with indolinone compounds | FLT3, FLI1, MCL1 | KDR 71/4885FLT1 6/4885ALK 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.