Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.75 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727106 | 1.00 | HRH3 (0.75) | HRH3HTR3AKCNH2 | |
| SCHEMBL6727074 | 1.00 | HRH3 (0.75) | HRH3HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL1178628 | 0.99 | HRH3 (0.74) | HRH3HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL1178730 | 0.99 | HRH3 (0.74) | HRH3HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL1178709 | 0.99 | HRH3 (0.74) | HRH3HTR3AKCNH2 | |
| Dimethylamine SCHEMBL2939116 | 0.97 | HRH3 (0.72) | HRH3HTR3AKCNH2 | |
| SCHEMBL1178737 | 0.92 | HRH3 (0.75) | HRH3HTR3AKCNH2 | |
| SCHEMBL1178847 | 0.91 | HRH3 (0.74) | HRH3HTR3AKCNH2 | |
| SCHEMBL1180016 | 0.91 | HRH3 (0.74) | HRH3HTR3AKCNH2 | |
| SCHEMBL1179147 | 0.91 | HRH3 (0.71) | HRH3HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2221298-B1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-8193176-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2012-06-05 | — | — | US | disclosed |
| US-8193176-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2012-06-05 | — | — | US | disclosed |
| US-8183387-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2012-05-22 | — | — | US | disclosed |
| US-8183387-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2012-05-22 | — | — | US | disclosed |
| US-20110065667-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-20110065667-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-20110065668-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-20110065668-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-7888354-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2011-02-15 | — | — | US | disclosed |
| US-7888354-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2011-02-15 | — | — | US | disclosed |
| US-20100267687-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-10-21 | — | — | US | disclosed |
| US-20100267687-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-10-21 | — | — | US | disclosed |
| EP-2221298-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-08-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065668-A1 | PHENYLPYRAZOLE DERIVATIVES | PER2, CRY1, HCRTR1 | HRH3 5/4885HTR3A 7/4885KCNH2 1286/4885 |
| US-20110065667-A1 | PHENYLPYRAZOLE DERIVATIVES | PER2, CRY1, HCRTR1 | HRH3 5/4885HTR3A 7/4885KCNH2 1286/4885 |
| US-20100267687-A1 | PHENYLPYRAZOLE DERIVATIVES | PER2, CRY1, HCRTR1 | HRH3 5/4885HTR3A 7/4885KCNH2 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.