SCHEMBL6729634

SCHEMBL6729634

O=C(c1ncc(-c2cccc[n+]2[O-])nn1)N1CCN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 15/20 0.47
LMNA P02545 1/20 0.47
ALDH1A1 P00352 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
GAA P10253 1/20 0.46
F2 P00734 2/20 0.46
ATM Q13315 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6726703 0.89 F10 (0.49) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6727877 0.87 ALDH1A1 (0.58) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6734197 0.86 F10 (0.51) F10
SCHEMBL6730922 0.86 F10 (0.51) F10
SCHEMBL6725062 0.86 F10 (0.54) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6726217 0.85 F10 (0.47) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6732275 0.84 SMN1; SMN2 (0.56) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6733194 0.84 ATM (0.53) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6731474 0.84 HRH4 (0.41) F10LMNAALDH1A1SMN1; SMN2GAA
SCHEMBL6731480 0.84 GAA (0.36) F10LMNASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 F10 19/4885LMNA 1760/4885ALDH1A1 1316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.