Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726788 | 0.91 | DUT (0.51) | DUTBACE1MMP2MMP9ALDH1A1 | |
| SCHEMBL6726942 | 0.88 | DUT (0.44) | DUTBACE1MMP2MMP9ALDH1A1 | |
| SCHEMBL6724138 | 0.81 | DUT (0.55) | DUTMMP2MMP9ALDH1A1LMNA | |
| SCHEMBL7847823 | 0.80 | DUT (0.46) | DUTBACE1MMP2MMP9ALDH1A1 | |
| SCHEMBL6719609 | 0.79 | DUT (0.56) | DUTMMP2MMP9LMNAMMP1 | |
| SCHEMBL6723691 | 0.78 | DUT (0.48) | DUTLMNASMN1; SMN2 | |
| SCHEMBL6724062 | 0.78 | DUT (0.40) | DUTBACE1MMP2MMP9ALDH1A1 | |
| SCHEMBL6723951 | 0.78 | DUT (0.54) | DUTMMP2MMP9LMNAMMP1 | |
| SCHEMBL6722449 | 0.78 | DUT (0.41) | DUTBACE1MMP2MMP9ALDH1A1 | |
| SCHEMBL6722436 | 0.78 | DUT (0.53) | DUTMMP2MMP9LMNAMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |