Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15498353 | 1.00 | CYP2E1 (0.55) | CYP2E1NR1I2ALDH1A1 | |
| SCHEMBL671145 | 0.92 | CYP2E1 (0.65) | CYP2E1NR1I2ALDH1A1 | |
| SCHEMBL10207387 | 0.92 | CYP2E1 (0.65) | CYP2E1NR1I2ALDH1A1 | |
| SCHEMBL1441786 | 0.90 | CYP2E1 (0.53) | CYP2E1NR1I2ALDH1A1 | |
| SCHEMBL15124313 | 0.88 | CYP2E1 (0.62) | CYP2E1NR1I2 | |
| SCHEMBL10265383 | 0.88 | CYP2E1 (0.62) | CYP2E1NR1I2 | |
| SCHEMBL15124204 | 0.87 | CYP2E1 (0.59) | CYP2E1NR1I2 | |
| SCHEMBL15130735 | 0.87 | CYP2E1 (0.59) | CYP2E1NR1I2 | |
| SCHEMBL9961546 | 0.86 | CYP2E1 (0.49) | CYP2E1NR1I2 | |
| SCHEMBL1440071 | 0.86 | CYP2E1 (0.49) | CYP2E1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140065103-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-03-06 | — | — | US | disclosed |
| EP-2606041-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS | Vertex Pharmaceuticals Incorporated (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024363-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140065103-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS | GOT1, RNASE1, SLC10A1 | CYP2E1 275/4885NR1I2 1347/4885ALDH1A1 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.