Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | MC4R | P32245 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741794 | 0.91 | PTGS2 (0.64) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL27589155 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL6743252 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL6738720 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL6720097 | 0.84 | PTGS2 (0.63) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL6719266 | 0.80 | PTGS2 (0.58) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL6725405 | 0.80 | PTGS2 (0.60) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL6718369 | 0.78 | PTGS2 (0.59) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| Rofecoxib SCHEMBL4434618 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| Rofecoxib SCHEMBL14163950 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686390-B2 | DIHYDROFURANONYL- OR DIHYDROPYRROLINONYL-PHENYL COMPOUNDS CONTAINING SUBSTITUTED THIO, SULFOXIDE OR SULFONYL GROUPS | DR. REDDY'S LABORATORIES LIMITED (IN) | 2004-02-03 | — | — | US | claimed |
| CN-1443180-A | Novel compounds having anti-inflammatory activity, process for their preparation and pharmaceutical compositions containing them | REDDY LAB LTD (IN) | 2003-09-17 | — | — | CN | claimed |
| US-20020032230-A1 | Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LTD. | 2002-03-14 | — | — | US | claimed |
| US-6686390-B2 | DIHYDROFURANONYL- OR DIHYDROPYRROLINONYL-PHENYL COMPOUNDS CONTAINING SUBSTITUTED THIO, SULFOXIDE OR SULFONYL GROUPS | DR. REDDY'S LABORATORIES LIMITED (IN) | 2004-02-03 | — | — | US | disclosed |
| CN-1443180-A | Novel compounds having anti-inflammatory activity, process for their preparation and pharmaceutical compositions containing them | REDDY LAB LTD (IN) | 2003-09-17 | — | — | CN | disclosed |
| US-20020032230-A1 | Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LTD. | 2002-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032230-A1 | Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TPSAB1, ACE | PTGS2 190/4885PTGS1 42/4885ABCB11 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.