Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | SDHB | P21912 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352684 | 0.86 | CYP3A4 (0.45) | CYP3A4HPGDACHECA12CA1 | |
| SCHEMBL10364438 | 0.84 | MAPT (0.40) | SDHBNOTUMNPC1PKMKDM4E | |
| SCHEMBL9589647 | 0.84 | NR1H2 (0.51) | CYP3A4HPGDCA12CA1CA2 | |
| SCHEMBL10363011 | 0.83 | KDM4E (0.41) | CYP3A4HPGDSDHBNOTUMNPC1 | |
| SCHEMBL10364814 | 0.80 | MAPT (0.40) | CYP3A4HPGDACHECA12CA1 | |
| SCHEMBL15110977 | 0.79 | CDK8 (0.38) | CA2NPC1POLBALDH1A1LMNA | |
| SCHEMBL10364788 | 0.79 | KDM4E (0.38) | CYP3A4SDHBNOTUMNPC1PKM | |
| SCHEMBL10364482 | 0.76 | GABRP (0.39) | NOTUMNPC1PKMKDM4EALDH1A1 | |
| SCHEMBL10362921 | 0.75 | NR1H2 (0.48) | CYP3A4HPGDCA12CA1CA2 | |
| SCHEMBL10694814 | 0.74 | MAPT (0.44) | SDHBNOTUMKDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276204-A2 | Pyridine gametocides | Monsanto Company (US) | 1988-07-27 | — | — | EP | claimed |
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | LEE LEN F (US) | 2004-11-04 | — | — | US | disclosed |
| US-6794396-B2 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-09-21 | — | — | US | disclosed |
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-02-26 | — | — | US | disclosed |
| US-6605624-B1 | Preventing and/or treating atherosclerosis and other coronary artery diseases | PHARMACIA CORPORATION | 2003-08-12 | — | — | US | disclosed |
| EP-0181852-B1 | SUBSTITUTED 2,6-SUBSTITUTED PYRIDINE COMPOUNDS | Monsanto Company (US) | 1990-08-29 | — | — | EP | disclosed |
| EP-0276204-A3 | Pyridine gametocides | Monsanto Company (US) | 1989-06-07 | — | — | EP | disclosed |
| US-4789395-A | POST- AND PRE-EMERGENT | MONSANTO COMPANY (US) | 1988-12-06 | — | — | US | disclosed |
| EP-0276204-A2 | Pyridine gametocides | Monsanto Company (US) | 1988-07-27 | — | — | EP | disclosed |
| EP-0276204-A2 | Pyridine gametocides | Monsanto Company (US) | 1988-07-27 | — | — | EP | disclosed |
| US-4747871-A | 2,6-bis(trifluoromethyl)-3-hydroxycarbonyl pyridine, salts and gametocides | MONSANTO COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0258201-A1 | 5-Sulfur substituted pyridine monocarboxylic herbicides | Monsanto Company (US) | 1988-03-02 | — | — | EP | disclosed |
| US-4655816-A | PLANT GROWTH REGULATORS | MONSANTO COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0181852-A1 | Substituted 2,6-substituted pyridine compounds | Monsanto Company (US) | 1986-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, CES1, MTTP | CYP3A4 391/4885HPGD 2470/4885ACHE 2714/4885 |
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, MTTP, LCAT | CYP3A4 330/4885HPGD 2389/4885ACHE 2731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.