Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FURIN | P09958 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734905 | 1.00 | LMNA (0.61) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2704783 | 0.78 | MEN1 (0.47) | LMNACYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL265248 | 0.78 | LMNA (0.57) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2185353 | 0.78 | LMNA (0.57) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2067685 | 0.78 | FURIN (0.44) | LMNACYP1A2CA9ALDH1A1MAPT | |
| SCHEMBL6846692 | 0.78 | FURIN (0.44) | LMNACYP1A2CA9ALDH1A1MAPT | |
| SCHEMBL15053148 | 0.78 | CYP19A1 (0.50) | LMNAPOLBALDH1A1MAPTKDM4E | |
| SCHEMBL23837603 | 0.76 | LMNA (0.53) | LMNAPOLBCYP1A2CA1CA2 | |
| Water SCHEMBL11590419 | 0.76 | LMNA (0.55) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5415127 | 0.76 | MAPT (0.50) | POLBCYP1A2CYP2C19CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686496-B1 | 4-OXO-2 BUTENOIC ACID AND 3-HYDRAZINO-2,4-DIOXOBUTANOIC ACID DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA | 2004-02-03 | — | — | US | disclosed |