Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.70 |
| ▸ | CCND1 | P24385 | 3/20 | 0.70 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.70 |
| ▸ | CDK1 | P06493 | 2/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.70 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622268 | 0.90 | HDAC8 (0.68) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL4622274 | 0.90 | HDAC8 (0.68) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL7228424 | 0.90 | CCNB2 (0.61) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL7228421 | 0.90 | CCNB2 (0.61) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL865350 | 0.86 | MAOA (0.58) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL6735219 | 0.86 | HDAC8 (0.53) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL7229340 | 0.84 | CDK4 (0.68) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL7229336 | 0.84 | CDK4 (0.68) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL7909151 | 0.83 | PTGER3 (0.68) | HDAC8PTPN1PTGER1PTGER4PTGER3 | |
| SCHEMBL7191225 | 0.83 | PTGER3 (0.68) | HDAC8PTPN1PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6761922-B2 | MIXING AN ASPARTYL DIPEPTIDE ESTER COMPOUND OR SALT WITH A SOLID FILLER SELECTED FROM SUGAR, SUGAR ALCOHOL, OLIGOSACCHARIDE AND POLYSACCHARIDE | AJINOMOTO CO., INC. (JP) | 2004-07-13 | — | — | US | disclosed |
| US-20040105928-A1 | Sweetener compositions and uses thereof | AJINOMOTO CO. INC (JP) | 2004-06-03 | — | — | US | disclosed |
| US-6652901-B2 | Sweetener compositions and uses thereof | AJINOMOTO CO., INC. (JP) | 2003-11-25 | — | — | US | disclosed |
| US-6649784-B2 | Reductive alkylation of aspartame with aldehyde | AJINOMOTO CO., INC. (JP) | 2003-11-18 | — | — | US | disclosed |
| US-20030065210-A1 | Aspartyl dipeptide ester derivatives and sweeteners | AJINOMOTO CO. INC. (JP) | 2003-04-03 | — | — | US | disclosed |
| US-20030059511-A1 | Sweetener compositions and uses thereof | AJINOMOTO CO., INC. (JP) | 2003-03-27 | — | — | US | disclosed |
| US-20030044502-A1 | Sweetener compositions containing aspartyl dipeptide ester compounds | AJINOMOTO CO. INC (JP) | 2003-03-06 | — | — | US | disclosed |
| EP-1223175-A1 | SOLID SWEETENER COMPOSITIONS, LIQUID SWEETENER COMPOSITIONS AND UTILIZATION THEREOF | Ajinomoto Co., Inc. (JP) | 2002-07-17 | — | — | EP | disclosed |
| EP-1221448-A1 | SWEETENER COMPOSITIONS WITH HIGH DEGREE OF SWEETNESS HAVING IMPROVED SWEETNESS, CORRIGENTS AND UTILIZATION THEREOF | Ajinomoto Co., Inc. (JP) | 2002-07-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065210-A1 | Aspartyl dipeptide ester derivatives and sweeteners | DNPEP, DPP4, DPP3 | CDK4 1817/4885CCND1 3470/4885CCNB2 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.