Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.68 |
| ▸ | CDK4 | P11802 | 3/20 | 0.65 |
| ▸ | CCND1 | P24385 | 3/20 | 0.65 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.65 |
| ▸ | CDK1 | P06493 | 2/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.65 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622268 | 1.00 | HDAC8 (0.68) | HDAC8CDK4CCND1CCNB2CDK1 | |
| SCHEMBL7272006 | 0.91 | CDK4 (0.68) | HDAC8CDK4CCND1CCNB2CDK1 | |
| SCHEMBL7272001 | 0.91 | CDK4 (0.68) | HDAC8CDK4CCND1CCNB2CDK1 | |
| SCHEMBL6735216 | 0.90 | CDK4 (0.70) | HDAC8CDK4CCND1CCNB2CDK1 | |
| SCHEMBL7228421 | 0.89 | CCNB2 (0.61) | HDAC8CDK4CCND1CCNB2CDK1 | |
| SCHEMBL7228424 | 0.89 | CCNB2 (0.61) | HDAC8CDK4CCND1CCNB2CDK1 | |
| SCHEMBL1311076 | 0.87 | HDAC8 (0.65) | HDAC8MAPTKDM4EPOLBHTT | |
| SCHEMBL20006886 | 0.85 | HDAC8 (0.66) | HDAC8MAPTKDM4EPOLBHTT | |
| SCHEMBL6035013 | 0.84 | HDAC8 (0.80) | HDAC8MAPTKDM4EPOLBHTT | |
| SCHEMBL6035015 | 0.84 | HDAC8 (0.80) | HDAC8MAPTKDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070726-B1 | ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS | AJINOMOTO KK (JP) | 2008-02-20 | — | — | EP | disclosed |
| CN-1192036-C | Novel aspartyl dipeptide ester derivatives and sweeteners | AJINOMOTO KK (JP) | 2005-03-09 | — | — | CN | disclosed |
| CN-1181090-C | Aspartyl dipeptide ester derivatives and sweeteners | ֮����ʽ���� | 2004-12-22 | — | — | CN | disclosed |
| US-6761922-B2 | MIXING AN ASPARTYL DIPEPTIDE ESTER COMPOUND OR SALT WITH A SOLID FILLER SELECTED FROM SUGAR, SUGAR ALCOHOL, OLIGOSACCHARIDE AND POLYSACCHARIDE | AJINOMOTO CO., INC. (JP) | 2004-07-13 | — | — | US | disclosed |
| US-20040105928-A1 | Sweetener compositions and uses thereof | AJINOMOTO CO. INC (JP) | 2004-06-03 | — | — | US | disclosed |
| US-6652901-B2 | Sweetener compositions and uses thereof | AJINOMOTO CO., INC. (JP) | 2003-11-25 | — | — | US | disclosed |
| US-6630191-B1 | Such as N-(N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-L-alpha-aspartyl)-L -(alphamethyl)phenylalanine-1-methyl ester; stability; safety | AJINOMOTO CO., INC. (JP) | 2003-10-07 | — | — | US | disclosed |
| US-6548096-B1 | Aspartyl dipeptide ester derivatives and sweeteners | AJINOMOTO CO., INC. (JP) | 2003-04-15 | — | — | US | disclosed |
| CN-1407991-A | Solid sweetener composition, liquid sweetener composition, and use thereof | AJINOMOTO KK (JP) | 2003-04-02 | — | — | CN | disclosed |
| US-20030059511-A1 | Sweetener compositions and uses thereof | AJINOMOTO CO., INC. (JP) | 2003-03-27 | — | — | US | disclosed |
| US-20030044502-A1 | Sweetener compositions containing aspartyl dipeptide ester compounds | AJINOMOTO CO. INC (JP) | 2003-03-06 | — | — | US | disclosed |
| CN-1378557-A | Sweetener compositions with high degree of sweeteness having improved sweeteness, corrigents and utilization thereof | AJINOMOTO KK (JP) | 2002-11-06 | — | — | CN | disclosed |
| EP-1223175-A1 | SOLID SWEETENER COMPOSITIONS, LIQUID SWEETENER COMPOSITIONS AND UTILIZATION THEREOF | Ajinomoto Co., Inc. (JP) | 2002-07-17 | — | — | EP | disclosed |
| EP-1221448-A1 | SWEETENER COMPOSITIONS WITH HIGH DEGREE OF SWEETNESS HAVING IMPROVED SWEETNESS, CORRIGENTS AND UTILIZATION THEREOF | Ajinomoto Co., Inc. (JP) | 2002-07-10 | — | — | EP | disclosed |
| CN-1307585-A | Novel aspartyl dipeptide ester derivatives and sweeteners | AJINOMOTO KK (JP) | 2001-08-08 | — | — | CN | disclosed |
| CN-1296493-A | Aspartyl dipeptide ester derivatives and sweeteners | AJINOMOTO KK (JP) | 2001-05-23 | — | — | CN | disclosed |
| EP-1088829-A1 | NOVEL ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS | Ajinomoto Co., Inc. (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-1070726-A1 | ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS | Ajinomoto Co., Inc. (JP) | 2001-01-24 | — | — | EP | disclosed |