Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726339 | 0.92 | KDM4E (0.40) | ALDH1A1HPGDNPSR1PKMMAPT | |
| SCHEMBL27370826 | 0.87 | ALDH1A1 (0.36) | ALDH1A1HPGDGAANPC1PKM | |
| SCHEMBL10373401 | 0.81 | MEN1 (0.33) | NPSR1NPC1PKMMEN1KMT2A | |
| SCHEMBL10371231 | 0.81 | MEN1 (0.33) | NPSR1NPC1PKMMEN1KMT2A | |
| SCHEMBL10561410 | 0.80 | MEN1 (0.33) | GAANPC1PKMKDM4EMEN1 | |
| SCHEMBL9726392 | 0.80 | GCGR (0.32) | CFTR | |
| SCHEMBL10371573 | 0.80 | CFTR (0.33) | ALDH1A1HPGDGAANPC1PKM | |
| SCHEMBL9726396 | 0.79 | GCGR (0.32) | — | |
| SCHEMBL8693608 | 0.79 | GCGR (0.34) | — | |
| SCHEMBL6727164 | 0.79 | KDM4E (0.38) | ALDH1A1HPGDNPSR1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | LEE LEN F (US) | 2004-11-04 | — | — | US | disclosed |
| US-6794396-B2 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-09-21 | — | — | US | disclosed |
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-02-26 | — | — | US | disclosed |
| US-6605624-B1 | Preventing and/or treating atherosclerosis and other coronary artery diseases | PHARMACIA CORPORATION | 2003-08-12 | — | — | US | disclosed |
| WO-1999041237-A1 | SUBSTITUTED PYRIDINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | G.D. SEARLE & CO. (US) | 1999-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, CES1, MTTP | ALDH1A1 1154/4885HPGD 2470/4885GAA 1749/4885 |
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, MTTP, LCAT | ALDH1A1 1364/4885HPGD 2389/4885GAA 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.