Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10602408 | 0.87 | TSHR (0.43) | TSHRSLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL7455701 | 0.79 | TSHR (0.37) | TSHRSLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL6743136 | 0.77 | TDP1 (0.47) | SLC1A3SLC1A2SLC1A1TDP1 | |
| SCHEMBL421627 | 0.76 | TSHR (0.48) | TSHRSLC7A5TDP1CHRM2CHRM4 | |
| SCHEMBL421683 | 0.76 | TSHR (0.48) | TSHRTDP1CHRM2CHRM4CHRM1 | |
| SCHEMBL1442538 | 0.75 | TSHR (0.50) | TSHRSLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL7092944 | 0.75 | TSHR (0.50) | TSHRSLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL255602 | 0.75 | TSHR (0.50) | TSHRSLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL13849512 | 0.75 | TSHR (0.50) | TSHRSLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL42203 | 0.75 | TSHR (0.50) | TSHRSLC1A3SLC1A2SLC1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831176-B2 | Reacting a ketoaldonic acid methyl ester of the sugar with the protected hydroxyl groups with a an alkylamine or hydroxyalamine salt in an organic solvent with a tert-amine to react with acid generated to produce oxime methyl ester | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-12-14 | — | — | US | claimed |
| US-20030204091-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | MICHIGAN STATE UNIVERSITY | 2003-10-30 | — | — | US | claimed |
| US-20030204092-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2003-10-30 | — | — | US | claimed |
| US-20030109710-A1 | PROCESS FOR THE PREPARATION OF 1,5-DIDEOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2003-06-12 | — | — | US | claimed |
| US-20020068819-A1 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-06-06 | — | — | US | claimed |
| US-20020052506-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-05-02 | — | — | US | claimed |
| US-20020052505-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-05-02 | — | — | US | claimed |
| US-20020016447-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-02-07 | — | — | US | claimed |
| US-20020016448-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-02-07 | — | — | US | claimed |
| US-20010049443-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2001-12-06 | — | — | US | claimed |
| US-6831176-B2 | Reacting a ketoaldonic acid methyl ester of the sugar with the protected hydroxyl groups with a an alkylamine or hydroxyalamine salt in an organic solvent with a tert-amine to react with acid generated to produce oxime methyl ester | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-12-14 | — | — | US | disclosed |
| US-6740780-B2 | L-XYLO-5-HEXULOSONIC ACID HYDRAZIDE OXIME | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-05-25 | — | — | US | disclosed |
| US-6683185-B2 | FROM HYDROXYL-PROTECTED OXIME INTERMEDIATES, INCLUDES FORMATION OF A LACTAM WHICH IS REDUCED TO THE HEXITOL; CHEMICAL INTERMEDIATES TO D-DIDEOXYGALACTO-NOJIRIMYCINS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-01-27 | — | — | US | disclosed |
| US-6653480-B2 | Generating aldonic-5-oxime ethyl ester with protected hydroxyls; obtain keto-methyl sugar ester, incubate with hydroxylamine hydrochloride, separate oxime methyl ester from mixture | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-11-25 | — | — | US | disclosed |
| US-6653482-B2 | The ketoaldonic acid methyl ester is converted into the oxime which is then reduced to the amine which cyclizes to give the lactam which is then reduced to the imino sugar by borane or a metal hydride | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-11-25 | — | — | US | disclosed |
| US-20020052506-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-05-02 | — | — | US | disclosed |
| US-20020052505-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-05-02 | — | — | US | disclosed |
| US-20020016447-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-02-07 | — | — | US | disclosed |
| US-20020016448-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-02-07 | — | — | US | disclosed |
| US-20010049443-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2001-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016448-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20010049443-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2459/4885SLC1A3 4285/4885SLC1A2 4087/4885 |
| US-20030109710-A1 | PROCESS FOR THE PREPARATION OF 1,5-DIDEOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20020052506-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20020068819-A1 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20030204092-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20020016447-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20030204091-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
| US-20020052505-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TSHR 2493/4885SLC1A3 4233/4885SLC1A2 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.