Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | PGD | P52209 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608220 | 0.83 | TDP1 (0.47) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL8653297 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL10750103 | 0.81 | TDP1 (0.49) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL2565616 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL7152465 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL7148849 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL8652316 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL7145527 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL18040638 | 0.81 | TDP1 (0.73) | TDP1POLBMAPK1ABCB1PGD | |
| SCHEMBL7150930 | 0.80 | TDP1 (0.77) | TDP1POLBMAPK1ABCB1PGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831176-B2 | Reacting a ketoaldonic acid methyl ester of the sugar with the protected hydroxyl groups with a an alkylamine or hydroxyalamine salt in an organic solvent with a tert-amine to react with acid generated to produce oxime methyl ester | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-12-14 | — | — | US | disclosed |
| US-6740780-B2 | L-XYLO-5-HEXULOSONIC ACID HYDRAZIDE OXIME | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-05-25 | — | — | US | disclosed |
| US-6683185-B2 | FROM HYDROXYL-PROTECTED OXIME INTERMEDIATES, INCLUDES FORMATION OF A LACTAM WHICH IS REDUCED TO THE HEXITOL; CHEMICAL INTERMEDIATES TO D-DIDEOXYGALACTO-NOJIRIMYCINS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-01-27 | — | — | US | disclosed |
| US-6653480-B2 | Generating aldonic-5-oxime ethyl ester with protected hydroxyls; obtain keto-methyl sugar ester, incubate with hydroxylamine hydrochloride, separate oxime methyl ester from mixture | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-11-25 | — | — | US | disclosed |
| US-6653482-B2 | The ketoaldonic acid methyl ester is converted into the oxime which is then reduced to the amine which cyclizes to give the lactam which is then reduced to the imino sugar by borane or a metal hydride | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-11-25 | — | — | US | disclosed |
| US-6649766-B2 | From hydroxyl-protected oxime intermediates, includes formation of a lactam which is reduced to the hexitol; chemical intermediates to D-dideoxygalacto-nojirimycins | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-11-18 | — | — | US | disclosed |
| US-20030204091-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | MICHIGAN STATE UNIVERSITY | 2003-10-30 | — | — | US | disclosed |
| US-20030204092-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2003-10-30 | — | — | US | disclosed |
| US-6605724-B2 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2003-08-12 | — | — | US | disclosed |
| US-6590121-B2 | The ketoaldonic acid methyl ester is converted into the oxime which is then reduced to the amine which cyclizes to give the lactam which is then reduced to the imino sugar by borane or a metal hydride | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2003-07-08 | — | — | US | disclosed |
| US-20030109710-A1 | PROCESS FOR THE PREPARATION OF 1,5-DIDEOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2003-06-12 | — | — | US | disclosed |
| US-6462197-B2 | REACTING A KETOALDONIC ACID METHYL ESTER OF THE SUGAR WITH THE PROTECTED HYDROXYL GROUPS WITH AN ALKYLAMINE OR HYDROXYAMINE ACID SALT WITH A TERTIARY AMINE TO REACT WITH AN ACID GENERATED IN THE REACTION TO PRODUCE OXIME METHYL ESTER | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2002-10-08 | — | — | US | disclosed |
| US-20020068819-A1 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-06-06 | — | — | US | disclosed |
| US-20020052506-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2002-05-02 | — | — | US | disclosed |
| US-20020052505-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-05-02 | — | — | US | disclosed |
| US-20020016447-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-02-07 | — | — | US | disclosed |
| US-20020016448-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2002-02-07 | — | — | US | disclosed |
| US-20010049443-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2001-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016448-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20010049443-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3290/4885POLB 2784/4885MAPK1 267/4885 |
| US-20030109710-A1 | PROCESS FOR THE PREPARATION OF 1,5-DIDEOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20020052506-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20020068819-A1 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20030204092-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20020016447-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20030204091-A1 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
| US-20020052505-A1 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines | GALE, HK1, G6PD | TDP1 3081/4885POLB 2687/4885MAPK1 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.