Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 10/20 | 0.37 |
| ▸ | HNF4A | P41235 | 3/20 | 0.35 |
| ▸ | RXRB | P28702 | 4/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6736672 | 1.00 | CYP3A4 (0.48) | CYP3A4CYP26A1CYP26B1MGLLRXRA | |
| SCHEMBL7770208 | 0.91 | CYP26A1 (0.47) | CYP3A4CYP26A1CYP26B1RXRAHNF4A | |
| SCHEMBL7770210 | 0.91 | CYP26A1 (0.47) | CYP3A4CYP26A1CYP26B1RXRAHNF4A | |
| SCHEMBL8480695 | 0.85 | CYP3A4 (0.53) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL8480699 | 0.85 | CYP3A4 (0.53) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL6732613 | 0.82 | CYP3A4 (0.71) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL8094159 | 0.80 | CYP3A4 (0.56) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL7769471 | 0.78 | CYP26A1 (0.50) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL7769473 | 0.78 | CYP26A1 (0.50) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL6735362 | 0.74 | CYP3A4 (0.54) | CYP3A4CYP26A1CYP26B1RXRAHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040162339-A1 | Heterocyclic biaryl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | DIAZ PHILIPPE (FR) | 2004-08-19 | — | — | US | disclosed |
| US-5981776-A | FOR USE IN HUMAN OR VETERINARY MEDICINE (DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL COMPLAINTS IN PARTICULAR), OR ALTERNATIVELY IN COSMETIC COMPOSITIONS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162339-A1 | Heterocyclic biaryl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | TYR, MITF, CYP1B1 | CYP3A4 147/4885CYP26A1 144/4885CYP26B1 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.