Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781293 | 0.86 | TDP1 (0.54) | SMN1; SMN2TDP1GPR35TSHRALDH1A1 | |
| SCHEMBL1374438 | 0.85 | GPR35 (0.48) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL3599344 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL6741088 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL11032366 | 0.81 | TSHR (0.52) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL1668133 | 0.81 | TDP1 (0.48) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL11668086 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL3393735 | 0.79 | GPR35 (0.46) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL7166893 | 0.79 | TDP1 (0.46) | SMN1; SMN2PDE7ATDP1GPR35TSHR | |
| SCHEMBL4692661 | 0.77 | PDE7A (0.46) | SMN1; SMN2PDE7ATDP1GPR35TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689771-B2 | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-6376665-B1 | ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-23 | — | — | US | disclosed |