SCHEMBL6737524

SCHEMBL6737524

CC(C)(C)[Si](OCCC1CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1c1ncc(-c2ccncc2)cn1)(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.38
LSS P48449 2/20 0.36
ATM Q13315 1/20 0.35
HSD11B1 P28845 1/20 0.34
F2 P00734 1/20 0.33
LMNA P02545 2/20 0.33
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6730827 0.93 F10 (0.39) F10LSSATMHSD11B1F2
SCHEMBL6728509 0.90 HSD11B1 (0.35) F10HSD11B1F2PTGDR2MEN1
Hydrochloric Acid SCHEMBL6732263 0.88 F10 (0.40) F10F2
SCHEMBL6734085 0.82 F10 (0.47) F10LSSATMF2LMNA
Hydrochloric Acid SCHEMBL6734058 0.81 F10 (0.41) F10F2
SCHEMBL6734052 0.79 F10 (0.40) F10F2
SCHEMBL6729796 0.79 F10 (0.46) F10LSSATMF2
SCHEMBL6737189 0.78 F10 (0.41) F10F2LMNAKDM4ESMN1; SMN2
SCHEMBL6738044 0.77 F10 (0.46) F10LSSF2
SCHEMBL6729636 0.77 F10 (0.46) F10LSSATMF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 F10 19/4885LSS 1745/4885ATM 2080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.