SCHEMBL6739042

SCHEMBL6739042

[CH2]Cc1c(C)cccc1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD44 P16070 1/20 0.50
CYP3A4 P08684 4/20 0.46
TDP1 Q9NUW8 3/20 0.46
TSHR P16473 3/20 0.44
PIK3CA P42336 1/20 0.44
ATP4A P20648 2/20 0.41
ATP4B P51164 2/20 0.41
ALDH1A1 P00352 5/20 0.37
HPGD P15428 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2A6 P11509 1/20 0.35
HSD17B10 Q99714 1/20 0.35
DPP4 P27487 1/20 0.34
KDM4E B2RXH2 2/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
ALOX15 P16050 1/20 0.33
CASP1 P29466 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL201782 0.83 CYP2A6 (0.43) CD44CYP3A4TDP1TSHRALDH1A1
SCHEMBL3667054 0.81 CD44 (0.54) CD44CYP3A4TDP1TSHRPIK3CA
Ethylene SCHEMBL27537107 0.80 CD44 (0.48) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL455161 0.79 CD44 (0.52) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL2009339 0.79 CD44 (0.52) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL30417664 0.79 CD44 (0.52) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL31606366 0.79 CD44 (0.52) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL6344760 0.79 CD44 (0.52) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL8285847 0.77 CD44 (0.50) CD44CYP3A4TDP1TSHRPIK3CA
SCHEMBL20841387 0.77 CD44 (0.50) CD44CYP3A4TDP1TSHRPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6689771-B2 TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-02-10 US disclosed
US-6376665-B1 ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-04-23 US disclosed
EP-1165500-A1 AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE Du Pont Pharmaceuticals Company (US) 2002-01-02 EP disclosed
WO-2000059874-A1 NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE DU PONT PHARMACEUTICALS COMPANY (US) 2000-10-12 WO disclosed