SCHEMBL6740132

SCHEMBL6740132

Nc1ccccc1C(F)(F)CF

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.39
ALOX15 P16050 2/20 0.39
CYP3A4 P08684 2/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
IDO1 P14902 2/20 0.35
L3MBTL1 Q9Y468 3/20 0.35
ALDH1A1 P00352 2/20 0.35
TDP1 Q9NUW8 2/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
POLB P06746 1/20 0.33
MEN1 O00255 2/20 0.32
MAPT P10636 2/20 0.32
KMT2A Q03164 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30664032 0.80 ALDH1A1 (0.38) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
SCHEMBL70554 0.75 ALDH1A1 (0.48) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
SCHEMBL29882203 0.75 ALDH1A1 (0.48) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
SCHEMBL8994564 0.75 ALDH1A1 (0.48) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
SCHEMBL6173073 0.74 IDO1 (0.41) IDO1L3MBTL1ALDH1A1TDP1HTR2C
SCHEMBL6447368 0.74 TSHR (0.42) ALOX15CASP1CASP7L3MBTL1ALDH1A1
Hydrochloric Acid SCHEMBL4371044 0.73 TDP1 (0.52) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
Fluoride SCHEMBL7897532 0.73 POLB (0.46) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
Ammonia Solution, Strong SCHEMBL8056717 0.73 POLB (0.46) SMN1; SMN2ALOX15CYP3A4CASP1CASP7
Hydrogen Sulfide SCHEMBL11147516 0.73 POLB (0.46) SMN1; SMN2ALOX15CYP3A4CASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016183101-A1 PALLADIUM-CATALYZED ARYLATION OF FLUOROALKYLAMINES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-11-17 WO disclosed
WO-2016183101-A1 PALLADIUM-CATALYZED ARYLATION OF FLUOROALKYLAMINES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-11-17 WO disclosed
US-6685793-B2 PHOTOPOLYMERIZATION; EXPOSURE TO ACTINIC, ULTRAVIOLET RADIATION 3M INNOVATIVE PROPERTIES COMPANY 2004-02-03 US disclosed
US-4059626-A Trifluoroethylanilines PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-11-22 US disclosed
US-4059626-A Trifluoroethylanilines PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-11-22 US disclosed
US-4036962-A BACTERICIDES E. I. DU PONT DE NEMOURS AND CO. (US) 1977-07-19 US disclosed