Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | NRAS | P01111 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23292472 | 1.00 | MAPK8 (0.44) | MAPK8FLT3SYKAURKBMKNK1 | |
| Hydrochloric Acid SCHEMBL23292386 | 0.75 | IKBKB (0.55) | MAPK8FLT3AURKBMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL23292382 | 0.75 | IKBKB (0.55) | MAPK8FLT3AURKBMKNK1MKNK2 | |
| SCHEMBL23292345 | 0.72 | MAPK8 (0.54) | MAPK8FLT3SYKAURKBMKNK1 | |
| SCHEMBL23292348 | 0.72 | MAPK8 (0.54) | MAPK8FLT3SYKAURKBMKNK1 | |
| SCHEMBL13295147 | 0.72 | HPGDS (0.48) | MKNK1MKNK2PIM1 | |
| SCHEMBL28063327 | 0.71 | HRH3 (0.42) | MKNK1MKNK2 | |
| SCHEMBL2636155 | 0.71 | HTR2C (0.39) | — | |
| SCHEMBL2636703 | 0.71 | IDO1 (0.39) | — | |
| SCHEMBL13294782 | 0.70 | MKNK1 (0.56) | MKNK1MKNK2PRKD2PIM1IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3813819-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| CN-112638373-A | Cyclin-dependent kinase inhibitors | 金耐特生物制药公司 | 2021-04-09 | — | — | CN | disclosed |