SCHEMBL6740498

SCHEMBL6740498

COC(=O)CCC1(CCC(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)C(=O)OC)CCC(=O)N1C

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.50
ITGA4 P13612 20/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6741757 0.88 ITGB1 (0.57) ITGB1ITGA4
SCHEMBL6743017 0.84 ITGB1 (0.50) ITGB1ITGA4
SCHEMBL15147586 0.73 ITGB1 (0.64) ITGB1ITGA4
SCHEMBL15147585 0.73 ITGB1 (0.64) ITGB1ITGA4
SCHEMBL6627877 0.73 ITGB1 (0.88) ITGB1ITGA4
SCHEMBL6742874 0.73 ITGA4 (0.52) ITGB1ITGA4
SCHEMBL6637068 0.72 ITGB1 (0.80) ITGB1ITGA4
SCHEMBL27519787 0.72 ITGB1 (0.80) ITGB1ITGA4
SCHEMBL6639157 0.72 ITGB1 (0.80) ITGB1ITGA4
SCHEMBL6625626 0.72 ITGB1 (0.83) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6685617-B1 4-(((-1-CARBOXY-2-(4-((2,6-DICHLOROBENZOYL)AMINE)PHENYL)ETHYL) AMINO)CARBONYL)-3-OXO-3-THIAZOLIDINEBUTANOIC ACID, USED AS ANTAGONISTS FOR CELLULAR ADHESION MOLECULES, AND ADMINISTERED AS ANTIINFLAMMATORY AGENTS PHARMACIA & UPJOHN COMPANY 2004-02-03 US disclosed