Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 6/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 4/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL674115 | 1.00 | SLC6A12 (0.39) | SLC6A12IDH1CNR1CNR2HPGD | |
| SCHEMBL10091473 | 0.98 | SLC6A12 (0.41) | SLC6A12IDH1CNR1CNR2HPGD | |
| SCHEMBL674065 | 0.98 | SLC6A12 (0.41) | SLC6A12IDH1CNR1CNR2HPGD | |
| SCHEMBL674066 | 0.98 | SLC6A12 (0.41) | SLC6A12IDH1CNR1CNR2HPGD | |
| 2-Methoxyethanol SCHEMBL675312 | 0.89 | CNR1 (0.39) | SLC6A12IDH1CNR1CNR2PTGES | |
| 2-Methoxyethanol SCHEMBL675311 | 0.89 | CNR1 (0.39) | SLC6A12IDH1CNR1CNR2PTGES | |
| SCHEMBL672045 | 0.89 | CNR1 (0.42) | SLC6A12IDH1CNR1CNR2HPGD | |
| SCHEMBL672044 | 0.89 | CNR1 (0.42) | SLC6A12IDH1CNR1CNR2HPGD | |
| SCHEMBL674098 | 0.84 | PTGES (0.47) | SLC6A12IDH1CNR1CNR2HPGD | |
| SCHEMBL674097 | 0.84 | PTGES (0.47) | SLC6A12IDH1CNR1CNR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606046-A1 | 2-(ARYLAMINO)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MPGES-1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022792-A1 | 2-(ARYLAMINO)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MPGES-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |