Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742481 | 0.77 | MEN1 (0.54) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL6739516 | 0.77 | SMN1; SMN2 (0.50) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10595270 | 0.75 | MEN1 (0.58) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL28716946 | 0.72 | NPSR1 (0.44) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL20536883 | 0.71 | MEN1 (0.76) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL10531285 | 0.71 | ELOVL6 (0.42) | PGR | |
| SCHEMBL11826152 | 0.71 | MEN1 (0.48) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL9190550 | 0.70 | MEN1 (0.74) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL29922159 | 0.70 | POLB (0.39) | MEN1KMT2AFTOPOLBALDH1A1 | |
| SCHEMBL9776773 | 0.69 | MEN1 (0.56) | MEN1KMT2AFTOPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689808-B2 | TREATING OR PREVENTING EPILEPSY OR NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2004-02-10 | — | — | US | claimed |
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-11-27 | — | — | US | claimed |
| EP-1320528-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-06-25 | — | — | EP | claimed |
| WO-2002000638-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | INSTITUTE OF MATERIA MEDICA (CN) | 2002-01-03 | — | — | WO | claimed |
| US-6689808-B2 | TREATING OR PREVENTING EPILEPSY OR NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2004-02-10 | — | — | US | disclosed |
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-11-27 | — | — | US | disclosed |
| EP-1320528-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002000638-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | INSTITUTE OF MATERIA MEDICA (CN) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | NR5A2, NR2E3, NR4A1 | MEN1 2571/4885KMT2A 1077/4885FTO 3528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.