Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742969 | 0.80 | KDM4E (0.41) | KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL6746418 | 0.80 | KDM4E (0.41) | KDM4EMAPT | |
| SCHEMBL28724813 | 0.78 | PTPN22 (0.46) | PTPN22 | |
| SCHEMBL721648 | 0.77 | GABRA1 (0.52) | PTPN22 | |
| SCHEMBL2012510 | 0.77 | PTPN22 (0.48) | PTPN22 | |
| Water SCHEMBL28257828 | 0.76 | GABRA1 (0.50) | PTPN22 | |
| SCHEMBL12829649 | 0.75 | VKORC1 (0.48) | — | |
| SCHEMBL15345708 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1GAAMAPTPTPN22 | |
| SCHEMBL29354413 | 0.74 | — | — | |
| SCHEMBL130289 | 0.74 | PTPN22 (0.58) | PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689777-B2 | DEPOLYMERIZING HEMOZOIN USING 2-IMINO-NAPHTHO(1,2-D)THIAZOL-5-OL DERIVATIVES | KENNETH S. WARREN INSTITUTE | 2004-02-10 | — | — | US | disclosed |