Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL9243364 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL4347209 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29152423 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29152415 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673489 | 0.97 | — | — | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL98496 | 0.97 | — | — | |
| Malic Acid SCHEMBL31673494 | 0.97 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL89131 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250255887-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. | 2025-08-14 | — | — | US | claimed |
| EP-4521952-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | Balchem Corporation (US) | 2025-03-19 | — | — | EP | claimed |
| US-12128057-B2 | Dietary nutrient compositions | Natals, Inc. (US) | 2024-10-29 | — | — | US | claimed |
| US-12128056-B2 | Dietary nutrient compositions | Natals, Inc. (US) | 2024-10-29 | — | — | US | claimed |
| WO-2023220606-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORPORATION (US) | 2023-11-16 | — | — | WO | claimed |
| US-20230357280-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORPORATION | 2023-11-09 | — | — | US | claimed |
| US-20220305033-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. | 2022-09-29 | — | — | US | claimed |
| US-20220096499-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. | 2022-03-31 | — | — | US | claimed |
| CN-113679040-A | Solid beverage for improving insulin sensitivity of type II diabetes mellitus people | 上海英库商务咨询有限公司 | 2021-11-23 | — | — | CN | claimed |
| US-11083738-B2 | Dietary nutrient compositions | Natals, Inc. (US) | 2021-08-10 | — | — | US | claimed |
| WO-2019067924-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. (US) | 2019-04-04 | — | — | WO | claimed |
| US-20180280430-A1 | COMPOSITION FOR IMPROVED PERFORMANCE | BALCHEM CORPORATION | 2018-10-04 | — | — | US | claimed |
| EP-3355989-A1 | COMPOSITION FOR IMPROVED PERFORMANCE | Balchem Corporation (US) | 2018-08-08 | — | — | EP | claimed |
| US-8728535-B2 | Nutritional supplement for use under physiologically stressful conditions | VERTICAL PHARMACEUTICALS, LLC (US) | 2014-05-20 | — | — | US | claimed |
| US-20130004570-A1 | NUTRITIONAL SUPPLEMENT FOR USE UNDER PHYSIOLOGICALLY STRESSFUL CONDITIONS | VERTICAL PHARMACEUTICALS, INC. (US) | 2013-01-03 | — | — | US | claimed |
| US-8202546-B2 | Nutritional supplement for use under physiologically stressful conditions | VERTICAL PHARMACEUTICALS, INC. (US) | 2012-06-19 | — | — | US | claimed |
| US-20100136104-A1 | NUTRITIONAL SUPPLEMENT FOR USE UNDER PHYSIOLOGICALLY STRESSFUL CONDITIONS | CIBC BANK USA | 2010-06-03 | — | — | US | claimed |
| US-20100080856-A1 | Method and composition for postoperative wound healing | COSTANTINO PETER D | 2010-04-01 | — | — | US | claimed |
| US-12496289-B2 | Methods of increasing magnesium bioavailability and absorption | BALCHEM CORPORATION (US) | 2025-12-16 | — | — | US | disclosed |
| WO-1998033494-A1 | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF VASCULAR DEGENERATIVE DISEASES | KOSBAB JOHN V (US) | 1998-08-06 | — | — | WO | disclosed |