Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.66 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 7/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13499600 | 0.84 | CHKA (0.90) | CHKAMETMCHR1 | |
| SCHEMBL26174901 | 0.79 | TNIK (0.60) | CHKAMETSRCTNIK | |
| SCHEMBL12067508 | 0.77 | TNIK (0.73) | METSRCTNIK | |
| SCHEMBL24483261 | 0.77 | CDK6 (0.68) | — | |
| SCHEMBL29684300 | 0.77 | CDK6 (0.68) | — | |
| Hydrochloric Acid SCHEMBL29684352 | 0.77 | CDK6 (0.67) | — | |
| SCHEMBL6738636 | 0.76 | CHKA (0.58) | CHKAMETSRCTNIK | |
| SCHEMBL21565581 | 0.72 | CHKA (0.60) | CHKANPC1RAB9A | |
| SCHEMBL27317684 | 0.72 | CHKA (0.78) | CHKAMETNPC1POLBRAB9A | |
| SCHEMBL12386956 | 0.72 | ALDH1A1 (0.62) | NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |