Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 4/20 | 0.58 |
| ▸ | GNRHR | P30968 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743939 | 0.79 | CHKA (0.51) | CHKAGNRHRABL1SRCMETAP2 | |
| SCHEMBL6736739 | 0.78 | CHKA (0.50) | CHKAGNRHRMETABL1SRC | |
| SCHEMBL13499600 | 0.77 | CHKA (0.90) | CHKAGNRHRMC4RMET | |
| SCHEMBL6741474 | 0.76 | CHKA (0.66) | CHKAMETSRCTNIK | |
| SCHEMBL15111957 | 0.73 | CHKA (0.61) | CHKAGNRHR | |
| SCHEMBL23652808 | 0.71 | MEN1 (0.61) | CHKA | |
| Hydrochloric Acid SCHEMBL4768371 | 0.70 | PDGFRB (0.48) | JAK2JAK3 | |
| SCHEMBL8038019 | 0.70 | MC4R (0.51) | CHKAMC4RMETAP2 | |
| SCHEMBL25259256 | 0.69 | CHKA (0.53) | CHKA | |
| SCHEMBL6480799 | 0.69 | ASIC3 (0.54) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |