Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 3/20 | 0.44 |
| ▸ | S100A4 | P26447 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31448378 | 0.81 | ALDH1A1 (0.53) | ALDH1A1PGRTDP1CYP3A4PTPRC | |
| SCHEMBL21962048 | 0.81 | ALDH1A1 (0.53) | ALDH1A1PGRTDP1CYP3A4PTPRC | |
| SCHEMBL4845321 | 0.74 | PGR (0.57) | ALDH1A1PGRTDP1CYP3A4MEN1 | |
| SCHEMBL4849481 | 0.72 | PGR (0.65) | ALDH1A1PGRCASP3CYP1A2CASP1 | |
| SCHEMBL26624028 | 0.72 | ALDH1A1 (0.53) | ALDH1A1PGRTDP1CYP3A4PTPRC | |
| SCHEMBL11010153 | 0.71 | ALDH1A1 (0.45) | ALDH1A1TDP1CYP3A4PTPRCS100A4 | |
| SCHEMBL31217559 | 0.71 | ALDH1A1 (0.51) | ALDH1A1TDP1CYP3A4PTPRCS100A4 | |
| SCHEMBL727919 | 0.71 | ALDH1A1 (0.51) | ALDH1A1TDP1CYP3A4PTPRCS100A4 | |
| SCHEMBL3400352 | 0.70 | TDP1 (0.71) | ALDH1A1TDP1CYP3A4PTPRCS100A4 | |
| SCHEMBL8072999 | 0.70 | AKR1B1 (0.44) | ALDH1A1TDP1CYP3A4PTPRCS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689808-B2 | TREATING OR PREVENTING EPILEPSY OR NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2004-02-10 | — | — | US | claimed |
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-11-27 | — | — | US | claimed |
| EP-1320528-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-06-25 | — | — | EP | claimed |
| WO-2002000638-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | INSTITUTE OF MATERIA MEDICA (CN) | 2002-01-03 | — | — | WO | claimed |
| US-6689808-B2 | TREATING OR PREVENTING EPILEPSY OR NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2004-02-10 | — | — | US | disclosed |
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-11-27 | — | — | US | disclosed |
| EP-1320528-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002000638-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | INSTITUTE OF MATERIA MEDICA (CN) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | NR5A2, NR2E3, NR4A1 | ALDH1A1 1151/4885PGR 201/4885TDP1 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.