Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769285 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL3716522 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL12627927 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL9412272 | 0.73 | ALDH1A1 (0.78) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL27996103 | 0.71 | ALDH1A1 (0.74) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL4697569 | 0.71 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL31540525 | 0.70 | ALDH1A1 (0.45) | ALDH1A1KDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL29765370 | 0.69 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL28769173 | 0.69 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 | |
| SCHEMBL25232427 | 0.69 | ALDH1A1 (0.73) | ALDH1A1KDM4ESMN1; SMN2HTTIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |