SCHEMBL6741878

SCHEMBL6741878

CN(CCc1ccccn1)C(=O)N1CSC[C@@H]1C(=O)N[C@@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.51
ITGB1 P05556 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6741881 1.00 ITGA4 (0.51) ITGA4ITGB1
SCHEMBL7422961 0.86 ITGA4 (0.49) ITGA4ITGB1
SCHEMBL12166629 0.84 ITGA4 (0.62) ITGA4
SCHEMBL12462209 0.84 ITGA4 (0.62) ITGA4
SCHEMBL12446688 0.84 ITGA4 (0.62) ITGA4
SCHEMBL6453971 0.84 ITGA4 (0.62) ITGA4
SCHEMBL7424535 0.81 ITGB1 (0.41) ITGA4ITGB1
SCHEMBL6742913 0.80 ITGA4 (0.61) ITGA4
SCHEMBL6740927 0.79 ITGA4 (0.60) ITGA4
SCHEMBL6743975 0.79 ITGA4 (0.60) ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6685617-B1 4-(((-1-CARBOXY-2-(4-((2,6-DICHLOROBENZOYL)AMINE)PHENYL)ETHYL) AMINO)CARBONYL)-3-OXO-3-THIAZOLIDINEBUTANOIC ACID, USED AS ANTAGONISTS FOR CELLULAR ADHESION MOLECULES, AND ADMINISTERED AS ANTIINFLAMMATORY AGENTS PHARMACIA & UPJOHN COMPANY 2004-02-03 US disclosed