Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.60 |
| ▸ | CFTR | P13569 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22479158 | 0.85 | KMT2A (0.50) | MGAMCFTRKMT2ATDP1SLC6A2 | |
| SCHEMBL22515674 | 0.85 | KMT2A (0.50) | MGAMCFTRKMT2ATDP1SLC6A2 | |
| SCHEMBL20374140 | 0.83 | MAOB (0.64) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL20980982 | 0.83 | ALOX15 (0.52) | MGAMCFTRKMT2ACHRNB2CHRNA7 | |
| SCHEMBL25224216 | 0.83 | TDP1 (0.58) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL4982062 | 0.83 | ALOX15 (0.62) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL30464281 | 0.83 | ALOX15 (0.62) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL4816422 | 0.82 | MGAM (0.59) | MGAMCFTRKMT2ACHRNB2CHRNA7 | |
| SCHEMBL430324 | 0.82 | MGAM (0.59) | MGAMCFTRKMT2ALMNACHRNB2 | |
| SCHEMBL28566903 | 0.82 | LMNA (0.57) | KMT2ATDP1SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| US-6727237-B2 | Inhibitors of bacterial NAD synthetase | BROUILLETTE WAYNE J (US) | 2004-04-27 | — | — | US | disclosed |
| US-20040063758-A1 | INHIBITORS OF BACTERIAL NAD SYNTHETASE | BROUILLETTE WAYNE J (US) | 2004-04-01 | — | — | US | disclosed |
| US-6500852-B1 | ENZYME INHIBITORS OF BACTERIAL NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) ENZYME LYASES USED AS BACTERICIDES, MICROBIOCIDE, ANTISEPTICS OR ANTIBIOTICS | UNIVERSITY OF ALABAMA RESEARCH FOUNDATION | 2002-12-31 | — | — | US | disclosed |
| EP-1109805-A1 | INHIBITORS OF BACTERIAL NAD SYNTHETASE | The UAB Research Foundation (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-1047692-A1 | METHODS OF SYNTHESIZING AND SCREENING INHIBITORS OF BACTERIAL NAD SYNTHETASE ENZYME, COMPOUNDS THEREOF AND METHODS OF TREATING BACTERIAL AND MICROBIAL INFECTIONS WITH THESE INHIBITORS | THE UAB RESEARCH FOUNDATION (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000010996-A1 | INHIBITORS OF BACTERIAL NAD SYNTHETASE | THE UAB RESEARCH FOUNDATION (US) | 2000-03-02 | — | — | WO | disclosed |
| WO-1999036422-A1 | METHODS OF SYNTHESIZING AND SCREENING INHIBITORS OF BACTERIAL NAD SYNTHETASE ENZYME, COMPOUNDS THEREOF, AND METHODS OF TREATING BACTERIAL AND MICROBIAL INFECTIONS WITH INHIBITORS OF BACTERIAL NAD SYNTHETASE ENZYME | THE UAB RESEARCH FOUNDATION (US) | 1999-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063758-A1 | INHIBITORS OF BACTERIAL NAD SYNTHETASE | COASY, NADK, NQO1 | MGAM 361/4885CFTR 2039/4885KMT2A 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.