Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.50 |
| ▸ | AHR | P35869 | 3/20 | 0.47 |
| ▸ | CMA1 | P23946 | 2/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.43 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20924253 | 0.88 | PDE3B (0.57) | CRBNAHRGRIA1CACNG8BRD4 | |
| SCHEMBL6743691 | 0.82 | AHR (0.55) | CRBNAHRCMA1EIF2AK2KDM1A | |
| SCHEMBL16090265 | 0.82 | CRBN (0.52) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL6746667 | 0.80 | CRBN (0.48) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL6742551 | 0.79 | CRBN (0.50) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL13529011 | 0.78 | CRBN (0.61) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL6746640 | 0.78 | AHR (0.49) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL4262015 | 0.76 | MMP12 (0.58) | PDE3BPDE3APGRNPC1MAPT | |
| SCHEMBL5873746 | 0.76 | SLC6A11 (0.52) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL28543984 | 0.75 | CRBN (0.55) | CRBNAHRCMA1EIF2AK2GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |