Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.40 |
| ▸ | FEN1 | P39748 | 6/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749686 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1CA1CA2ALOX5AP | |
| SCHEMBL6742739 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL6745297 | 0.90 | PTGES2 (0.45) | PTGS2PTGS1CA1CA2ALOX5AP | |
| SCHEMBL6745215 | 0.90 | FEN1 (0.45) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL7048299 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1CA1CA2ALOX5AP | |
| SCHEMBL6746256 | 0.88 | ALOX5AP (0.41) | PTGS2PTGS1CA1CA2ALOX5AP | |
| SCHEMBL6747322 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CA1CA2ALOX5AP | |
| SCHEMBL6746710 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1SCN9A | |
| SCHEMBL6749461 | 0.86 | FEN1 (0.47) | PTGS2PTGS1CA1CA2ALOX5AP | |
| SCHEMBL6746038 | 0.86 | ALOX5AP (0.41) | PTGS2PTGS1CA1CA2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |