Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 7/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723136 | 0.91 | PTGS2 (0.51) | PTGS2PTGS1KMOCA1CA2 | |
| SCHEMBL6725390 | 0.91 | PTGS2 (0.45) | PTGS2PTGS1KMOCA1CA2 | |
| SCHEMBL7044091 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1KMOFEN1ALOX5AP | |
| SCHEMBL6729554 | 0.90 | PTGS2 (0.48) | PTGS2PTGS1KMOFEN1ALOX5AP | |
| SCHEMBL6723777 | 0.90 | KMO (0.46) | PTGS2PTGS1KMOCA1CA2 | |
| SCHEMBL6743290 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1CA1CA2FEN1 | |
| SCHEMBL6723355 | 0.88 | PTGS2 (0.42) | PTGS2PTGS1KMOCA1CA2 | |
| SCHEMBL6746048 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1KMOCA1CA2 | |
| SCHEMBL6725930 | 0.87 | PTGS2 (0.48) | PTGS2PTGS1KMOCA1CA2 | |
| SCHEMBL6728769 | 0.87 | FEN1 (0.46) | PTGS2PTGS1KMOCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |