SCHEMBL6743312

SCHEMBL6743312

O=C(O)c1cncc(C(=O)N2CCCC[C@H]2C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)C(=O)O)c1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.60
ITGB1 P05556 7/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6739192 0.81 ITGA4 (0.55) ITGA4ITGB1
SCHEMBL6561144 0.81 ITGB1 (0.70) ITGA4ITGB1
SCHEMBL6561093 0.77 ITGB1 (0.58) ITGA4ITGB1
SCHEMBL7260512 0.76 ITGB1 (0.77) ITGA4ITGB1
SCHEMBL6740694 0.75 ITGB1 (0.50) ITGA4ITGB1
SCHEMBL7422726 0.74 ITGA4 (0.55) ITGA4ITGB1
SCHEMBL8257645 0.74 ITGA4 (0.86) ITGA4ITGB1
SCHEMBL5201410 0.74 ITGA4 (0.87) ITGA4ITGB1
SCHEMBL6743406 0.73 ITGB1 (0.50) ITGA4ITGB1
SCHEMBL5203489 0.73 ITGA4 (0.80) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6685617-B1 4-(((-1-CARBOXY-2-(4-((2,6-DICHLOROBENZOYL)AMINE)PHENYL)ETHYL) AMINO)CARBONYL)-3-OXO-3-THIAZOLIDINEBUTANOIC ACID, USED AS ANTAGONISTS FOR CELLULAR ADHESION MOLECULES, AND ADMINISTERED AS ANTIINFLAMMATORY AGENTS PHARMACIA & UPJOHN COMPANY 2004-02-03 US disclosed