Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL29060945 | 0.95 | CA4 (0.52) | CA4CA1BBOX1FOLH1GPR84 | |
| SCHEMBL29566757 | 0.95 | CA4 (0.56) | CA4CA1BBOX1FOLH1GPR84 | |
| Zinc Ion SCHEMBL839513 | 0.95 | CA4 (0.52) | CA4CA1BBOX1FOLH1GPR84 | |
| SCHEMBL29686680 | 0.95 | CA4 (0.56) | CA4CA1BBOX1FOLH1GPR84 | |
| SCHEMBL6743367 | 0.95 | CA4 (0.52) | CA4CA1BBOX1FOLH1GPR84 | |
| SCHEMBL1614090 | 0.95 | CA4 (0.56) | CA4CA1BBOX1FOLH1GPR84 | |
| Alcohol SCHEMBL4580692 | 0.86 | CA1 (0.48) | CA4CA1BBOX1FOLH1GPR84 | |
| Malic Acid SCHEMBL220040 | 0.72 | CA4 (0.94) | CA4CA2NFKB1 | |
| D-Glutamate SCHEMBL6738795 | 0.72 | CA1 (0.48) | CA4CA1BBOX1FOLH1GPR84 | |
| Silver SCHEMBL6738610 | 0.72 | CA1 (0.48) | CA4CA1BBOX1FOLH1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686133-B2 | CONTAINING LIGHT-INSENSITIVE SILVER SALTS OF ORGANIC CARBOXYLIC ACIDS WITH ONE OR MORE CARBOXYLIC ACID AND A BINDER, EXCLUSIVE OF SILVER SUCCINATE SIMILAR COMPOUNDS | AGFA-GEVAERT (BE) | 2004-02-03 | — | — | US | disclosed |